Research

Selected Publications

Synapses and stress

Characterization of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus of Crh-IRES-Cre mutant mice. Wamsteeker Cusulin JI, Füzesi T, Watts AG, Bains JS. PLoS One. 2013 May 28;8(5):e64943. PMID: 23724107

Changing the tune: plasticity and adaptation of retrograde signals. Iremonger KJ, Wamsteeker Cusulin JI, Bains JS. Trends Neurosci. 2013 Aug;36(8):471-9. PMID: 23706151

Glucocorticoid feedback uncovers retrograde opioid signaling at hypothalamic synapses. Wamsteeker Cusulin JI, Füzesi T, Inoue W, Bains JS. Nat Neurosci. 2013 May;16(5):596-604. PMID: 23563581

Inoue W, Baimoukhametova DV, Füzesi T, Cusulin JI, Koblinger K, Whelan PJ, Pittman QJ, Bains JS. Nat Neurosci. 2013 May;16(5):605-12. PMID: 23563580

Short-term plasticity impacts information transfer at glutamate synapses onto parvocellular neuroendocrine cells in the paraventricular nucleus of the hypothalamus. Marty V, Kuzmiski JB, Baimoukhametova DV, Bains JS. J Physiol. 2011 Sep 1;589(Pt 17):4259-70. PMID: 21727221

Stress-induced priming of glutamate synapses unmasks associative short-term plasticity. Kuzmiski JB, Marty V, Baimoukhametova DV, Bains JS. Nat Neurosci. 2010 Oct;13(10):1257-64. PMID: 20818385

Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus. Wamsteeker JI, Kuzmiski JB, Bains JS. J Neurosci. 2010 Aug 18;30(33):11188-96. PMID: 20720126

Metaplasticity of hypothalamic synapses following in vivo challenge. Kuzmiski JB, Pittman QJ, Bains JS. Neuron. 2009 Jun 25;62(6):839-49. PMID: 19555652

Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis. Hewitt SA, Wamsteeker JI, Kurz EU, Bains JS. Nat Neurosci. 2009 Apr;12(4):438-43. PMID: 19252497

 

Retrograde signalling

Dual regulation of anterograde and retrograde transmission by endocannabinoids. Iremonger KJ, Kuzmiski JB, Baimoukhametova DV, Bains JS. J Neurosci. 2011 Aug 17;31(33):12011-20. PMID:21849561

Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits. Crosby KM, Inoue W, Pittman QJ, Bains JS. Neuron. 2011 Aug 11;71(3):529-41. PMID:21835348

Retrograde opioid signaling regulates glutamatergic transmission in the hypothalamus. Iremonger KJ, Bains JS. J Neurosci. 2009 Jun 3;29(22):7349-58. PMID: 19494156

Retrograde regulation of GABA transmission by the tonic release of oxytocin and endocannabinoids governs postsynaptic firing. Oliet SH, Baimoukhametova DV, Piet R, Bains JS. J Neurosci. 2007 Feb 7;27(6):1325-33. PMID:17287507

 

Glia in synaptic plasticity

Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses. Gordon GR, Iremonger KJ, Kantevari S, Ellis-Davies GC, MacVicar BA, Bains JS. Neuron. 2009 Nov 12;64(3):391-403. PMID: 19914187

Glia: they make your memories stick! Bains JS, Oliet SH. Trends Neurosci. 2007 Aug;30(8):417-24. Epub 2007 Jul 12. Review. PMID: 17631972

Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy. Gordon GR, Baimoukhametova DV, Hewitt SA, Rajapaksha WR, Fisher TE, Bains JS. Nat Neurosci. 2005 Aug;8(8):1078-86. PMID: 15995701

 

Synaptic Transmission in the hypothalamus

Integration of asynchronously released quanta prolongs the postsynaptic spike window. Iremonger KJ, Bains JS. J Neurosci. 2007 Jun 20;27(25):6684-91. PMID: 17581955

Brain-derived neurotrophic factor silences GABA synapses onto hypothalamic neuroendocrine cells through a postsynaptic dynamin-mediated mechanism. Hewitt SA, Bains JS. J Neurophysiol. 2006 Apr;95(4):2193-8. PMID: 16407427

Noradrenaline triggers multivesicular release at glutamatergic synapses in the hypothalamus. Gordon GR, Bains JS. J Neurosci. 2005 Dec 7;25(49):11385-95. PMID: 16339033

Dopamine modulates use-dependent plasticity of inhibitory synapses. Baimoukhametova DV, Hewitt SA, Sank CA, Bains JS. J Neurosci. 2004 Jun 2;24(22):5162-71. PMID: 15175385

Priming of excitatory synapses by alpha1 adrenoceptor-mediated inhibition of group III metabotropic glutamate receptors. Gordon GR, Bains JS. J Neurosci. 2003 Jul 16;23(15):6223-31. PMID: 12867506